Eduardo Perozo, Ph.D.
Professor Biological Sciences Division, Biochemistry and Molecular Biology
Biographical Info
Research Interest
The Perozo Lab studies the dynamics and conformational rearrangements of ion channels. As a result, we have developed expertise in electrophysiological measurements (including single molecule patch clamp analyses), reporter group spectroscopic approaches (EPR, Fluorescence), X-ray crystallography and membrane protein biochemistry/liposome reconstitution methods. Dr. Perozo coordinates the Membrane Protein Structural Dynamics Project and works with the executive committee to set priorities and allocate project funding and resources. He is also an active participant in the Membrane Protein Purification Expression Core, the Pilot 1 project dedicated towards the Structural Dynamics of Hormone-Receptor Action, and the Bridge 4 Dynamics of Ion Permeation and Conformational Coupling.
Honors and Awards
Nobel Forum: Invited Speaker, Nobel Symposium on Oxygen Biology, Stockholm Sweden (2004)
Featured Publications
- Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor
- Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel
- Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy
- Structural Dynamics of the MscL C-terminal Domain
- The gating cycle of a K+ channel at atomic resolution
- Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation
Training
- Ph.D., 1990, University of California at Los Angeles, Physiology
- Graduated, 1985, Universidad Central de Venezuela, Biology
