Gökhan M. Mutlu, M.D. » Members

Biographical Info

Research Interest

We have a longstanding interest in studying the mechanisms of cardiopulmonary diseases including acute lung injury, repair and fibrosis in response to different stimuli including influenza, LPS and particulate matter air pollution. Specifically, our research focuses on investigating the role of cellular metabolism including mitochondrial function and reactive oxygen species in the pathogenesis of cardiopulmonary diseases. We study the mechanisms that cellular metabolism regulate in different cell types including lung epithelial cells, macrophages, fibroblasts and endothelial cells.

Honors and Awards

Alfred Pick-Academic Excellence Award, Michael Reese Hospital, Chicago, Illinois (1997)
Fellow of the year award, Department of Medicine, University of Illinois, Chicago, Illinois (1998)
Fellow of the year award, Department of Medicine, University of Illinois, Chicago, Illinois (1999)
Research Career Development Award, ENH Research Institute, Evanston, Illinois (2001)
Young Investigator Award, Northwestern Memorial Foundation (2004)
Young Investigator Award, Chest Foundation, American College of Chest Physicians (2004)
Outstanding New Environmental Scientist (ONES) Award, NIEHS (2006)
Excellence in Teaching Award, Northwestern University Feinberg School of Medicine (2007)
Elected member, American Society for Clinical Investigation (2013)

Featured Publications

• Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts
• Update in Chronic Obstructive Pulmonary Disease 2018
• Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β
• Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis
• Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1
• Particulate Matter Air Pollution: Effects on the Cardiovascular System

Training

• M.D., 1992, Istanbul University, Medicine