Julian Solway, M.D.
Professor of Medicine Director, Institute for Translational MedicineDepartment of Medicine
Biographical Info
Research Interest
I am Dean for Translational Medicine and founding Director of the Institute for Translational Medicine, home of the University of Chicago’s NIH/NCATS CTSA award. I have served the CTSA Consortium as a co-Chair, Steering Committee member, and co-Chair of the Strategic Goal 3 and Collaboration/Engagement Domain Task Force. My research programs primarily address asthma. I have extensive experience studying airway smooth muscle (ASM) function and dysfunction in asthma, having studied smooth muscle specific gene transcription, protein accumulation, and hypertrophy, and signaling mechanisms that regulate these; ASM contraction and its reversal, and the mechanisms that regulate these; and ASM mediated-airway narrowing, airway constrictor responsiveness, and lung function in both animal models and humans. Additional studies address asthma genetics and therapeutics in mechanistic and therapeutic clinical studies and preclinical development of novel asthma treatments. Recently, I have focused on the inhibition of pulmonary fibrosis and on the inhibition of breast cancer metastasis using novel small molecules discovered in our asthma studies. I directed the University of Chicago’s NHLBI-sponsored T32 Research Training Program in Respiratory Biology for over 20 years, led or co-led two NHLBI Multidisciplinary K12 Training Programs, and currently co-lead an NIH Broadening Experiences in Scientific Training (BEST) award.
Honors and Awards
Tau Beta Pi (1979)
Eta Kappa Nu (1979)
American Society for Clinical Investigation (1991)
ACP-ASIM Award for Outstanding Work in Science as Related to Medicine (2001)
Association of American Physicians (2005)
UChicago Dept of Medicine Arthur H. Rubenstein Mentorship Award (2008)
Joseph R. Rodarte Award for Scientific Distinction, Am Thoracic Soc Resp Struct & Function Assembly (2010)
Featured Publications
- Loss of bronchoprotection with ICS+LABA, beta-receptor dynamics, and the effect of alendronate
- Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling
- Associations between environmental quality and adult asthma prevalence in medical claims data
- SM22 is required for the maintenance of actin-rich structures generated during bacterial infections
- Preexisting Type 2 Immune Activation Protects against the Development of Sepsis
- Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma
Training
- M.D., 1978, Harvard University, Medicine
- B.S., 1974, Massachusetts Institute of Technology, Electrical Engineering
