Nanduri R. Prabhakar, Ph.D., D.Sc.
Harold Hines Jr. Professor of Medicine Director, Center for Systems Biology & Oxygen SensingDepartment of Medicine
Biographical Info
Research Interest
Oxygen sensing by the Carotid body; Gas transmitter signaling, Sleep apnea; Molecular mechanisms of adaptations and mal-adaptations to intermittent hypoxia.
Honors and Awards
Nobel Forum: Invited Speaker, Nobel Symposium on Oxygen Biology, Stockholm Sweden (2004)
Plenary Lecture, O2 Homeostasis, University of Cardiff, U.K. (2005)
Plenary Lecture, Brazilian Physiological Society (2005)
Dr. P.C.Roy Oration Award. Indian Physiological Society (2007)
A.S. Paintal Award, University of Delhi (2008)
Neil S. Cherniack Lecture, Case Western Reserve University, Cleveland. (2008)
Plenary Lecture. British Physiological Soc. Birmingham, UK. (2010)
Julius H.Comroe Distinguished Lecture Award American Physiological Society (2012)
Mario Toppo Distinguished Scientist Award, ASIOA (2013)
Prof. Mahabalinos Award, Physiological Society of India (2014)
Plenary Lecture, PanAm Physiological Congress, Brazil (2014)
Inaugural C. von Euler Lecture, Karolinska Nobel Institutet, Stockholm, Sweden (2014)
Elected Foreign Member of National Academy of Sciences India. (2015)
Plenary Lecture, Oxford Meeting, Sydney, Australia (2015)
Inaugural Lahiri-Cherniack Lecture, American Physiological Society (2016)
Michael de Burgh Daly Award, Physiological Society, U.K. (2016)
AAIMS Silver Jubilee Oration Award (2017)
Elected Fellow of the American Physiological Society (2017)
Featured Publications
- Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea
- DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity
- Complementary roles of gasotransmitters CO and H2S in sleep apnea
- H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea
- Protein kinase G-regulated production of H2S governs oxygen sensing
- Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats
- Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema
- Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
- H2S mediates O2 sensing in the carotid body
Training
- Ph.D., 1980, M.S. University, Baroda, India, Physiology
- D.Sc, 1982, Ruhr University, Bochum, Germany, Biology
