Nicholai Dublin, Ph.D.
Associate Professor of Medicine Department of Medicine
Biographical Info
Research Interest
Dr. Nickolai Dulin studies the signaling mechanisms of myofibroblast differentiation as related to the pathogenesis of pulmonary fibrosis. This includes the signaling induced by TGF-beta and by G protein coupled receptors, control of cell signaling by actin and microtubule sytoskeleton, activation of mechanosensitive transcription factors and identification of their target genes, and control of these processes through protein phosphorylation. His studies using cultured human lung fibroblasts and animal models of pulmonary fibrosis aim to identify new signaling molecules that could be targeted for potential treatment of this disease.
Featured Publications
- Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts
- Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β
- P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation
- Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation
- Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
- Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis
For a complete list of publications click here:
Training
- Ph.D., 1990, Moscow State University, Biology
- M.S., 1987, Moscow State University, Biology
Categories: Member
