William N. Green, Ph.D.
Professor Department of Neurobiology
Biographical Info
Research Interest
My research is focused on the cell biology of ionotropic neurotransmitter receptors, the receptors responsible for the rapid postsynaptic response in nerve and muscle. These receptors are large oligomeric membrane proteins with subunits surrounding an ion channel that opens when neurotransmitters bind to the receptor. There are two different families of ionotropic neurotransmitter receptors. One family includes nicotinic acetylcholine receptors (AChRs), GABA and glycine receptors, and the other family covers the ionotropic glutamate receptors. There are several projects ongoing in my lab characterizing the assembly, trafficking and clustering of these receptors.
Honors and Awards
Inaugural Albert & Ellen Grass Faculty Award from the Grass Foundation (2002–2005)
Distinguished Research Visitor Award from the University of Auckland (2006)
Stephen W. Kuffler Research Award from the MBL (2010)
Herbert W. Rand and the Colwin Endowed Summer Research Fellowship from the MBL (2011)
Fellow at Advanced Imaging Center at Howard Hughes Medical Institute Janelia Research Campus (2017 & 2018
Featured Publications
- A novel function for the ER retention signals in the C-terminus of kainate receptor subunit, GluK5
- Development of fluorescence imaging probes for nicotinic acetylcholine α4β2∗ receptors
- Correction: Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes
- Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes
- Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation
- S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects
Training
- Ph.D., 1986, Cornell University Graduate School of Medical Sciences, Physiology and Biophysics
- B.Sc, 1978, University College, University of Toronto
