At the first IWRTH, a consensus statement was issued establishing the nomenclature of thyroid hormone receptor ß-gene mutations in resistance to thyroid hormone (J. Clin. Endocrinol. Metab. 78:990-3, 1994; Clin Endocrinol. 697-700, 1994; Eur J Endocrinol. 130:426-8, 1994; J Endocrinol Invest. 17:283-7, 1994). At the third IWRTH the first mouse models of RTH were presented and their role in advancing the understanding of the mechanism of thyroid hormone action was discussed. At the seventh IWRTH it was proposed to broaden the definition of thyroid hormone hyposensitivity to encompass all defects that can interfere with the biological activity of a chemically intact thyroid hormone secreted in normal or excessive amounts. The term reduced sensitivity to thyroid hormone (RSTH) was adopted at the eight IWRTH and the newly identified syndromes caused by defects of thyroid hormone cell membrane transport and metabolism were added to the program. Also the term “thyroid hormone action” was added to the name of the workshop to better define the field of interest. At the tenth IWRTH, based on presentations and discussions, a committee was established to classify and propose a nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism, bringing to light the term Impaired sensitivity to thyroid hormone (ISTH) to encompass all these defects (Thyroid, 24:407-409, 2014; J Clin Endocrinol Metab. 99:768-770, 2014; Eur Thyroid J. 3:7-9, 2014). At the twelfth IWRTH a task force was set to establish a more precise nomenclature for Thyroid hormone signaling pathways (Endocrinology, 158:2052-2057, 2017). This attests to the leadership role of the workshops.
List of Past Workshops
- 1st: Magdalene College, Cambridge, UK, July 10-11, 1993
- 2nd: Villa Contarini, Piazzola sul Brenta, Padua, Italy, May 12-13, 1995
- 3rd: Aspen, Colorado, USA, October 12-14, 1997
- 4th: São Paulo, Brazil, May 23- 25,1999
- 5th: Villa Caramora (Verbania) Italy, June 6-8, 2001
- 6th: Ocean Point Resort and Club, Miami Beach, Florida, USA September 13-15, 2003
- 7th: Ecole Normale Supérieure, Lyon, France, September 19-21, 2005
- 8th: Ponta Delgada, Azores, Portugal, October 9-11, 2007
- 9th: Magdalene College, Cambridge, United Kingdom, September 8-11, 2010
- 10th: Manoir Saint Castin, Quebec, Canada, September 17-19, 2012
- 11th: San Lorenzo de El Escorial, Madrid, Spain, September 3-6, 2014
- 12th: Colorado Springs, USA, September 18-21, 2016
- 13th: Landgoed Zonheuvel, Doorn, The Netherlands, September 11-14, 2018 (visit site)
